Rachel Lampert

Looking for participants: HCM and LQTS studies on exercise and lifestyle choices

Rachel Lampert, MD, Yale University

How do exercise and other lifestyle choices impact the well-being of patients with hypertrophic cardiomyopathy (HCM) or long QT syndrome (LQTS)? Although it is recommended that all patients with HCM and most patients with LQTS avoid most vigorous sports, the overall risks and benefits of exercise remain unknown.

To better understand how exercise and other lifestyle choices influence both clinical outcome and quality of life in patients with these disorders, Michael Ackerman, MD, PhD (Mayo Clinic), Sharlene Day, MD (University of Michigan), and I launched two exciting new NIH-funded studies: Lifestyle and Exercise in Hypertrophic Cardiomyopathy (LIVE-HCM) and Lifestyle and Exercise in Long QT (LIVE-LQT) (NIH R01 HL125918-01).

LIVE-HCM and LIVE-LQT are currently enrolling individuals, from 8 to 50 years old, both exercisers and non-exercisers, who have HCM, LQT, or carry a gene for either of these conditions. There are no geographic limitations to participation, which involves a telephone interview and filling out questionnaires online or by phone. Participants also receive a Fitbit pedometer to wear a few weeks per year (or more).

If you or one of your patients would like more information about joining the study, please visit:

HCM—present in one in five hundred individuals—is the most common genetic cardiovascular disease affecting the heart muscle. HCM causes the heart to become abnormally thick, which for some—though not all—people can cause symptoms. Similarly, LQTS is a genetic disease that affects the heart’s electrical system and is present in one in three thousand people. Vigorous exercise is restricted for many individuals with HCM and LQTS because safety risks are unknown; however, recent small studies have suggested that some individuals with LQTS who have been evaluated and appropriately treated in specialty LQTS centers may be able to participate in sports.

By better understanding how exercise and other lifestyle choices impact patients with HCM and LQT, we hope to be able to help patients lead full, healthy lives.